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. 1993 Mar;30(3):202-5.
doi: 10.1136/jmg.30.3.202.

Mapping of the X linked form of hyper IgM syndrome (HIGM1)

M Padayachee  1 , R J Levinsky, C Kinnon, A Finn, C McKeown, C Feighery, L D Notarangelo, R W Hendriks, A P Read, S Malcolm
Affiliations

Mapping of the X linked form of hyper IgM syndrome (HIGM1)

M Padayachee et al. J Med Genet. 1993 Mar.

Erratum in

  • J Med Genet 1993 Jun;30(6):528

Abstract

X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes.

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