Nitric oxide inhibition intensifies cold-restraint induced gastric ulcers in rats
- PMID: 8097477
- DOI: 10.1007/BF01923407
Nitric oxide inhibition intensifies cold-restraint induced gastric ulcers in rats
Abstract
Treatment 20 min beforehand with an inhibitor of nitric oxide (NO) synthesis NW-nitro-1-arginine methyl ester (L-NAME) (12.5, 25, 50 or 100 mg/kg, s.c.), dose-dependently intensified gastric glandular mucosal ulceration produced by cold-restraint stress. Hexamethonium (20 mg/kg) or atropine (1 mg/kg) pretreatment s.c. 20 min before stress strongly antagonised stress-evoked ulceration, as well as the ulcer-potentiating effects of L-NAME when either cholinoceptor antagonist was given concurrently with the NO inhibitor. Stress-induced mast cell degranulation was not worsened by L-NAME pretreatment. The findings suggest that NO could confer partial protection against stress-induced gastric ulcer formation; its activity is triggered off by the ulcerogenic mechanism of stress.
Similar articles
-
Cold restraint stress-induced gastric mucosal dysfunction. Role of nitric oxide.Dig Dis Sci. 1996 May;41(5):956-63. doi: 10.1007/BF02091537. Dig Dis Sci. 1996. PMID: 8625769
-
Effects of chronic nitric oxide synthase inhibition in cold-restraint and ethanol-induced gastric mucosal damage in rats.Digestion. 1996;57(1):60-6. doi: 10.1159/000201314. Digestion. 1996. PMID: 8626050
-
Prostaglandins, capsaicin-sensitive sensory nerves and neutrophil infiltration, but not nitric oxide, contribute to cold restraint stress-induced gastric adaptation in rats.Clin Exp Pharmacol Physiol. 2006 Oct;33(10):946-51. doi: 10.1111/j.1440-1681.2006.04469.x. Clin Exp Pharmacol Physiol. 2006. PMID: 17002672
-
Stress-induced gastric ulceration: its aetiology and clinical implications.Scand J Gastroenterol. 1992 Apr;27(4):257-62. doi: 10.3109/00365529209000071. Scand J Gastroenterol. 1992. PMID: 1375389 Review. No abstract available.
-
Stress ulceration in rats: impact of prior stress experience.Neurosci Biobehav Rev. 1991 Fall;15(3):319-26. doi: 10.1016/s0149-7634(05)80024-7. Neurosci Biobehav Rev. 1991. PMID: 1956600 Review.
Cited by
-
Protective effect of nitric oxide on development of acute pancreatitis in rats.Dig Dis Sci. 1995 Oct;40(10):2162-9. doi: 10.1007/BF02209000. Dig Dis Sci. 1995. PMID: 7587783
-
Effects of activated granulocytes and O2- on microcirculatory injury in acute gastric mucosal lesion in rats induced by sodium cinchophen.J Gastroenterol. 1996 Apr;31(2):153-60. doi: 10.1007/BF02389511. J Gastroenterol. 1996. PMID: 8680532
-
Cold restraint stress-induced gastric mucosal dysfunction. Role of nitric oxide.Dig Dis Sci. 1996 May;41(5):956-63. doi: 10.1007/BF02091537. Dig Dis Sci. 1996. PMID: 8625769
-
Nitric oxide as a mediator of gastrointestinal mucosal injury?-Say it ain't so.Mediators Inflamm. 1995;4(6):397-405. doi: 10.1155/S0962935195000640. Mediators Inflamm. 1995. PMID: 18475671 Free PMC article.
-
Effect of nitric oxide on integrity, blood flow and cyclic GMP levels in the rat gastric mucosa: modulation by sialoadenectomy.Br J Pharmacol. 1995 May;115(2):344-8. doi: 10.1111/j.1476-5381.1995.tb15883.x. Br J Pharmacol. 1995. PMID: 7545520 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources