Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33
- PMID: 8097486
- DOI: 10.1007/BF00218267
Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33
Abstract
We have determined the chromosomal location of the human genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase (GC-S). The study was performed by in situ hybridization of human metaphase spreads with two human cDNA probes, containing the coding sequences of the GC-S alpha 3 and beta 3 subunits, respectively. Each probe gave a strong specific signal on chromosome 4 at the 4q31.3-4q33 region, with the maximal signal in the 4q32 band. The colocalization of both genes in 4q32 represents an interesting feature for the coordinated regulation of expression of both GC-S subunits.
Similar articles
-
Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat.Hypertension. 1998 Jul;32(1):149-54. doi: 10.1161/01.hyp.32.1.149. Hypertension. 1998. PMID: 9674652
-
Expression of soluble guanylyl cyclase. Catalytic activity requires two enzyme subunits.FEBS Lett. 1990 Oct 15;272(1-2):221-3. doi: 10.1016/0014-5793(90)80489-6. FEBS Lett. 1990. PMID: 1977619
-
Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1-->q31.2 by in situ hybridization.Cytogenet Cell Genet. 2000;88(3-4):204-5. doi: 10.1159/000015548. Cytogenet Cell Genet. 2000. PMID: 10828587 No abstract available.
-
Guanylyl cyclases, a growing family of signal-transducing enzymes.FASEB J. 1991 Oct;5(13):2785-91. doi: 10.1096/fasebj.5.13.1680765. FASEB J. 1991. PMID: 1680765 Review.
-
Studying the structure and regulation of soluble guanylyl cyclase.Methods. 1999 Dec;19(4):485-93. doi: 10.1006/meth.1999.0891. Methods. 1999. PMID: 10581148 Review.
Cited by
-
Characterization of the human alpha1 beta1 soluble guanylyl cyclase promoter: key role for NF-kappaB(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor.J Biol Chem. 2008 Jul 18;283(29):20027-36. doi: 10.1074/jbc.M801223200. Epub 2008 May 12. J Biol Chem. 2008. PMID: 18474600 Free PMC article.
-
Release of nitric oxide from endothelial cells stimulated by YC-1, an activator of soluble guanylyl cyclase.Br J Pharmacol. 1999 Nov;128(6):1316-22. doi: 10.1038/sj.bjp.0702921. Br J Pharmacol. 1999. PMID: 10578147 Free PMC article.
-
Promoter activity of the 5'-flanking regions of medaka fish soluble guanylate cyclase alpha1 and beta1 subunit genes.Biochem J. 2002 Jan 15;361(Pt 2):337-45. doi: 10.1042/0264-6021:3610337. Biochem J. 2002. PMID: 11772405 Free PMC article.
-
Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner.J Clin Invest. 2002 Dec;110(11):1717-27. doi: 10.1172/JCI16588. J Clin Invest. 2002. PMID: 12464677 Free PMC article.
-
Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.Hum Genet. 1994 Jul;94(1):69-73. doi: 10.1007/BF02272844. Hum Genet. 1994. PMID: 8034296
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Molecular Biology Databases
Miscellaneous