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Case Reports
. 1993 Jun 5;341(8858):1439-40.
doi: 10.1016/0140-6736(93)90883-i.

Colorectal cancer in patients with X-linked agammaglobulinaemia

J W van der Meer  1 , R S Weening, P T Schellekens, I P van Munster, F M Nagengast
Affiliations
Free article
Case Reports

Colorectal cancer in patients with X-linked agammaglobulinaemia

J W van der Meer et al. Lancet. .
Free article

Abstract

Primary immunodeficiency disorders can predispose to certain malignancies but hitherto no such relation has been established for X-linked agammaglobulinaemia (XLA). We have diagnosed rapidly progressive colorectal cancer in 3 unrelated young adults with XLA. We could find no explanation for the tumours. Since the calculated incidence of rectosigmoid cancer is increased 30-fold in patients with XLA, we advise the screening of these individuals, and perhaps people with other agammaglobulinaemias, for colorectal cancer.

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