Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Jun 12;341(8859):1505-6.
doi: 10.1016/0140-6736(93)90636-u.

Effects of human growth hormone therapy on melanocytic naevi

J P Bourguignon  1 , G E Piérard, C Ernould, C Heinrichs, M Craen, P Rochiccioli, J E Arrese, C Franchimont
Affiliations
Free article

Effects of human growth hormone therapy on melanocytic naevi

J P Bourguignon et al. Lancet. .
Free article

Abstract

Melanocytic naevi may grow more rapidly during human growth hormone (hGH) therapy. With standardised skin photographs, the growth rate of the naevi was two-fold greater in 14 hypopituitary and 5 Turner's syndrome girls treated with hGH than in untreated patients or controls. HMB-45 immunoreactivity, a marker of stimulated melanocytes, was absent in naevi from 18 of 19 individuals not treated with hGH, including 5 Turner's syndrome patients studied 2-43 months after stopping hGH. In naevi from 39 hGH-treated patients, 22 showed unusual HMB-45 reactivity in dermal naevocytes. During administration of hGH, melanocytic naevi grow faster and there is reversible stimulation of naevocytes.

PubMed Disclaimer

Publication types