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Case Reports
. 1993 Jun;152(6):473-5.
doi: 10.1007/BF01955052.

Anti-neutrophil cytoplasmic auto-antibodies-associated vasculitis with pulmonary and renal involvement

G Pintos-Morell  1 , A Roca-Comas, M A Naranjo, C Tural, E Abad, G Javier, J Prats
Affiliations
Case Reports

Anti-neutrophil cytoplasmic auto-antibodies-associated vasculitis with pulmonary and renal involvement

G Pintos-Morell et al. Eur J Pediatr. 1993 Jun.

Abstract

We present a 13-year-old boy with a rapidly progressive glomerulonephritis and pulmonary haemorrhage with perinuclear anti-neutrophil cytoplasmic auto-antibodies (pANCA) corresponding to anti-myeloperoxidase antibodies. The diagnosis of microscopic polyarteritis was made on the basis of the clinical features, the positivity of pANCA, and the histological finding of a pauci-immune crescentic glomerulonephritis. He responded excellently to corticosteroids and cyclophosphamide therapy and complete clinical remission persists 1 year after withdrawal of treatment. We emphasize the usefulness of ANCA antibody assays to establish a prompt diagnosis and adequate treatment in systemic vasculitis in children.

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