doi: 10.1016/0140-6736(93)91475-2.
Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue
Affiliations
- PMID: 8101586
- DOI: 10.1016/0140-6736(93)91475-2
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Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue
Lancet.
.
Abstract
It is not clear whether the ophthalmopathy present in Graves' disease is related to autoimmune reactions to common thyroid/orbit components or is due to specific ocular antigens unrelated to the thyroid. In Graves' disease, serum antibodies to the thyrotropin receptor (TSH-R) can stimulate thyroid function, but no link between the TSH-R and ocular tissues has been found. We have shown, by polymerase chain reaction amplification of specific cDNA, that mature TSH-R mRNA is expressed in the retro-orbital tissue of both healthy subjects and patients with Graves' disease. Of other tissues and cells tested (fibroblasts, lymphocytes, muscle, and thyroid), only thyroid tissue expressed the TSH-R mRNA.
Comment in
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Graves' ophthalmopathy and the TSH receptor.Lancet. 1993 Aug 7;342(8867):318-9. doi: 10.1016/0140-6736(93)91467-z. Lancet. 1993. PMID: 8101579 No abstract available.
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