Case Reports
doi: 10.1016/0140-6736(93)92816-c.
Detection of trisomy 18 and Y-derived sequences in fetal nucleated cells obtained by transcervical flushing
Affiliations
- PMID: 8101904
- DOI: 10.1016/0140-6736(93)92816-c
Item in Clipboard
Case Reports
Detection of trisomy 18 and Y-derived sequences in fetal nucleated cells obtained by transcervical flushing
Lancet.
.
Abstract
A procedure which combines the collection of fetal cells by transcervical flushing and in situ hybridisation techniques on nuclei in interphase was used to detect trisomy 18 in a fetus at 12 weeks of gestation. Using a primed in situ labelling method, we could also detect Y-specific sequences in a small percentage of transcervically flushed cells obtained at 8-12 weeks from pregnant women with male fetuses. This approach seems to be suitable for prenatal diagnosis of major chromosomal abnormalities and other selected inherited disorders very early in gestation.
Comment in
-
Transcervical flushing and antenatal diagnosis.Lancet. 1993 Oct 16;342(8877):989-90. doi: 10.1016/0140-6736(93)92036-s. Lancet. 1993. PMID: 8105235 No abstract available.
Similar articles
-
Prenatal diagnosis with use of fetal cells isolated from maternal blood: five-color fluorescent in situ hybridization analysis on flow-sorted cells for chromosomes X, Y, 13, 18, and 21.Am J Obstet Gynecol. 1998 Jul;179(1):203-9. doi: 10.1016/s0002-9378(98)70273-x. Am J Obstet Gynecol. 1998. PMID: 9704788 Clinical Trial.
-
Prenatal diagnosis of partial trisomy 2q. Case report.Prenat Diagn. 1997 Sep;17(9):874-6. doi: 10.1002/(sici)1097-0223(199709)17:9<874::aid-pd149>3.0.co;2-a. Prenat Diagn. 1997. PMID: 9316134
-
Sonographic detection of fetuses with trisomies 13 and 18: accuracy and limitations.Am J Obstet Gynecol. 1988 Feb;158(2):404-9. doi: 10.1016/0002-9378(88)90165-2. Am J Obstet Gynecol. 1988. PMID: 3277433
-
Prenatal diagnosis of partial trisomy 1q using fluorescent in situ hybridization.Am J Med Genet. 1994 Mar 1;50(1):21-7. doi: 10.1002/ajmg.1320500105. Am J Med Genet. 1994. PMID: 8160748 Review.
-
First trimester prenatal diagnosis using transcervical cells: an evaluation.Hum Reprod Update. 1997 Jul-Aug;3(4):383-92. doi: 10.1093/humupd/3.4.383. Hum Reprod Update. 1997. PMID: 9459283 Review.
Cited by
-
Non-invasive early prenatal molecular diagnosis using retrieved transcervical trophoblast cells.Hum Genet. 1996 Feb;97(2):150-5. doi: 10.1007/BF02265257. Hum Genet. 1996. PMID: 8566945
-
Prenatal diagnosis of common aneuploidies in transcervical samples using quantitative fluorescent-PCR analysis.Mol Diagn Ther. 2007;11(2):117-21. doi: 10.1007/BF03256231. Mol Diagn Ther. 2007. PMID: 17397248
-
FISH detection of trisomy 21 in interphase by the simultaneous use of two differentially labelled cosmid contigs.J Med Genet. 1994 Sep;31(9):679-85. doi: 10.1136/jmg.31.9.679. J Med Genet. 1994. PMID: 7815435 Free PMC article.
-
Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies.Hum Reprod Update. 2018 Jul 1;24(4):484-496. doi: 10.1093/humupd/dmy008. Hum Reprod Update. 2018. PMID: 29608700 Free PMC article. Review.
-
Transcervical retrieval of fetal cells in the practice of modern medicine: a review of the current literature and future direction.Fertil Steril. 2010 Apr;93(6):1725-30. doi: 10.1016/j.fertnstert.2009.11.022. Epub 2010 Jan 13. Fertil Steril. 2010. PMID: 20056202 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
