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. 1993 Jul;72(7):1312-7.
doi: 10.3382/ps.0721312.

Identification of class II major histocompatibility complex polymorphisms predicted to be important in peptide antigen presentation

G T Pharr  1 , H D Hunt, L D Bacon, J B Dodgson
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Free article

Identification of class II major histocompatibility complex polymorphisms predicted to be important in peptide antigen presentation

G T Pharr et al. Poult Sci. 1993 Jul.
Free article

Abstract

Chickens of the B2, B5, B15, B19, and B21 B-congenic haplotypes differ in disease resistance. Complementary DNA from B-congenic chicken strains have been analyzed for allelic diversity of expressed Class II MHC genes. The predicted amino acid sequences of eight genes from five haplotypes were subjected to Wu-Kabat variability analysis. The B-L gene polymorphic regions and conserved regions are highly similar to the human leukocyte antigen Class II genes. Therefore, the present analysis reveals candidate polymorphisms important in determining the spectrum of antigenic peptides presented to T helper cells, and allelic differences possibly important in resistance to avian disease.

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