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Case Reports
. 1993 Sep 11;342(8872):651-2.
doi: 10.1016/0140-6736(93)91761-a.

Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy

K M Dolman  1 , R O Gans, T J Vervaat, G Zevenbergen, D Maingay, R E Nikkels, A J Donker, A E von dem Borne, R Goldschmeding
Affiliations
Case Reports

Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy

K M Dolman et al. Lancet. .

Abstract

Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during propylthiouracil treatment of hyperthyroidism. On withdrawal of the drug ANCA concentrations fell and clinical symptoms resolved completely.

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