Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1993 Jun;7(3):311-24.
doi: 10.1007/BF00880154.

Clinical significance of genetic influences on cardiovascular drug metabolism

L Arcavi  1 , N L Benowitz
Affiliations
Review

Clinical significance of genetic influences on cardiovascular drug metabolism

L Arcavi et al. Cardiovasc Drugs Ther. 1993 Jun.

Abstract

Inherited differences in metabolism may be responsible for individual variability in the efficacy of drugs and the occurrence of adverse drug reactions. Among the cardiovascular drugs reported to exhibit genetic polymorphism are debrisoquine, sparteine, some beta-adrenoceptor antagonists, flecainide, encainide, propafenone, nifedipine, procainamide, and hydralazine. The implications of genetic differences in the metabolism of these drugs for cardiovascular therapeutics is the subject of this review.

PubMed Disclaimer

References

    1. Br J Clin Pharmacol. 1987 Aug;24(2):213-20 - PubMed
    1. J Med Genet. 1980 Apr;17(2):102-5 - PubMed
    1. Clin Pharmacol Ther. 1985 Nov;38(5):509-18 - PubMed
    1. J Med Genet. 1984 Feb;21(1):27-33 - PubMed
    1. N Engl J Med. 1989 Mar 2;320(9):565-70 - PubMed