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Comparative Study
. 1993 Oct;67(10):6270-2.
doi: 10.1128/JVI.67.10.6270-6272.1993.

Congo red inhibition of scrapie agent replication

B Caughey  1 , D Ernst, R E Race
Affiliations
Comparative Study

Congo red inhibition of scrapie agent replication

B Caughey et al. J Virol. 1993 Oct.

Abstract

Congo red inhibits the accumulation of protease-resistant PrP in scrapie-infected mouse neuroblastoma cells. Here we show that Congo red also inhibits the replication of scrapie infectivity in these cells. This observation is consistent with the idea that protease-resistant PrP is a vital component of the scrapie agent or that agent replication depends on the presence of protease-resistant PrP in the cell.

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