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. 1975 Jul;28(1):67-74.
doi: 10.1080/09553007514550771.

Radiation-induced inhibition of RNA synthesis in Tetrahymena pyriformis

S G Ernst, R C Rustad, N L Oleinick

Radiation-induced inhibition of RNA synthesis in Tetrahymena pyriformis

S G Ernst et al. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Jul.

Abstract

Radiation-induced disturbances in RNA synthesis were investigated in exponentially growing Tetrahymena. Sub-lethal doses of gamma-radiation lead to a transient, dose-dependent decrease in the rate of total RNA synthesis measured by 3H-uridine incorporation, without an alteration of 3H-uridine uptake by the cells. The rate of 3H-uridine incorporation decreases exponentially with dose. In contrast, the duration of inhibition of RNA synthesis is linearly dependent on dose. Target-theory calculations suggest that the sensitive molecule has a molecular weight of about 2 X 10(7) Daltons.

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