Comparative Study
The resistance of HIV-infected chimpanzees to progression to AIDS correlates with absence of HIV-related T-cell dysfunction
Affiliations
- PMID: 8105093
Item in Clipboard
Comparative Study
The resistance of HIV-infected chimpanzees to progression to AIDS correlates with absence of HIV-related T-cell dysfunction
J Med Primatol.
1993 Feb-May.
Abstract
Differences in the in vivo and in vitro responses of T lymphocytes from chimpanzees and human subjects were compared for evidence of HIV-1 related T-cell dysfunction. There was no increased level of programmed cell death (PCD) in HIV-1 infected chimpanzees in contrast to asymptomatic individuals. Anergy could be induced with HIV-1 gp120 in human but not chimpanzee TH lymphocytes, however in vitro infection of chimpanzee TH cultures with HIV-1 resulted in complete lysis of cells within three weeks. These findings suggest that the resistance of HIV-1 infected chimpanzees to progression to AIDS is due to their relative resistance to the systemic effects of HIV-1 on T-cell dysfunction.
Similar articles
-
Human and simian immunodeficiency virus-infected chimpanzees do not have increased intracellular levels of beta-chemokines in contrast to infected humans.J Med Virol. 2003 Mar;69(3):297-305. doi: 10.1002/jmv.10289. J Med Virol. 2003. PMID: 12526038
-
Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 (CD95)-induced apoptosis and preservation of a T helper 1 phenotype.J Immunol. 1997 Mar 15;158(6):2964-76. J Immunol. 1997. PMID: 9058836
-
Apoptosis in SIV infection.Cell Death Differ. 2005 Aug;12 Suppl 1:979-90. doi: 10.1038/sj.cdd.4401600. Cell Death Differ. 2005. PMID: 15818408 Review.
-
HIV-induced T-lymphocyte depletion.Clin Lab Med. 1994 Jun;14(2):221-38. Clin Lab Med. 1994. PMID: 7924189 Review.
-
Immune strategies utilized by lentivirus infected chimpanzees to resist progression to AIDS.Immunol Lett. 1996 Jun;51(1-2):45-52. doi: 10.1016/0165-2478(96)02554-0. Immunol Lett. 1996. PMID: 8811344
Cited by
-
Increased neutralization sensitivity and reduced replicative capacity of human immunodeficiency virus type 1 after short-term in vivo or in vitro passage through chimpanzees.J Virol. 2000 Sep;74(17):7699-707. doi: 10.1128/jvi.74.17.7699-7707.2000. J Virol. 2000. PMID: 10933675 Free PMC article.
-
Extensive diversification of human immunodeficiency virus type 1 subtype B strains during dual infection of a chimpanzee that progressed to AIDS.J Virol. 1998 Apr;72(4):3005-17. doi: 10.1128/JVI.72.4.3005-3017.1998. J Virol. 1998. PMID: 9525623 Free PMC article.
-
Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells.J Exp Med. 1994 Aug 1;180(2):769-74. doi: 10.1084/jem.180.2.769. J Exp Med. 1994. PMID: 8046353 Free PMC article.
-
Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis.J Virol. 1996 Sep;70(9):6502-7. doi: 10.1128/JVI.70.9.6502-6507.1996. J Virol. 1996. PMID: 8709290 Free PMC article.
-
Modulation of gene expression in CD4+ T lymphocytes following in vitro HIV infection: a comparison between human and chimpanzee.Virusdisease. 2015 Jun;26(1-2):62-69. doi: 10.1007/s13337-015-0252-1. Epub 2015 Jun 6. Virusdisease. 2015. PMID: 26436123 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical