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. 1975 Oct;132(4):434-9.
doi: 10.1093/infdis/132.4.434.

A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates

H B Levy, G Baer, S Baron, C E Buckler, C J Gibbs, M J Iadarola, W T London, J Rice

A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates

H B Levy et al. J Infect Dis. 1975 Oct.

Abstract

A comlex of polyriboinosinic-polyribocytidylic acid (poly I-poly C) with poly-L-lysine and carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to hydrolysis by primate serum as the parent poly I-poly C. It has a thermal denaturation temperature about 40 C higher than that of poly I-poly C. The complex induces significant levels of serum interferon in monkeys and chimpanzees under conditions in which poly I-poly C itself induces no interferon.

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