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. 1993 Apr-Jun;37(2-3):113-22.

Oncogene elements within an endogenous retrovirus

K A Whartenby  1 , R A Insel, S M Freeman, P Keng, G N Abraham
Affiliations
  • PMID: 8105657

Oncogene elements within an endogenous retrovirus

K A Whartenby et al. Acta Virol. 1993 Apr-Jun.

Abstract

The human genome contains a large number of endogenous retroviral-related sequences. While the function of these sequences is unknown, they may contribute to disease processes through their regions of homology with infectious retroviruses. We have been further characterizing a recently reported HTLV-1 related endogenous retroviral sequence cloned from T lymphocytes isolated from a patient with essential cryoglobulinemia. We here report further detailed transcriptional analysis of the sequence for tissue and cell-cycle specificity and a novel finding of an association between the endogenous retrovirus and a ras-related gene.

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