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. 1993 Sep;110(1):20-2.
doi: 10.1111/j.1476-5381.1993.tb13765.x.

Release-regulating dopamine autoreceptors in human cerebral cortex

E Fedele  1 , G C Andrioli, A Ruelle, M Raiteri
Affiliations

Release-regulating dopamine autoreceptors in human cerebral cortex

E Fedele et al. Br J Pharmacol. 1993 Sep.

Abstract

Slices from fresh specimens of human neocortex which had to be removed during neurosurgery to reach subcortical tumours were labelled with [3H]-dopamine and stimulated electrically. Quinpirole, a selective dopamine D2 receptor agonist, inhibited the stimulated tritium overflow (EC50 = 25 nM; maximal inhibition: about 80% at 10 microM). The selective D1 receptor agonist, SKF 38393, was inactive up to 10 microM. Quinpirole was antagonized by the D2 receptor antagonist (-)-sulpiride (apparent pA2 = 8.26). Thus dopaminergic axon terminals in the human mesocortical pathway possess autoreceptors of the D2 type.

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