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Case Reports
. 1994 Feb;18(2):85-9.
doi: 10.1016/0145-2126(94)90123-6.

Richter's syndrome associated with loss of response to transforming growth factor-beta

P C Nowell  1 , J S Moore, F E Fox, R J Capocasale, J A Kant, E C Besa
Affiliations
Case Reports

Richter's syndrome associated with loss of response to transforming growth factor-beta

P C Nowell et al. Leuk Res. 1994 Feb.

Abstract

A patient with chronic lymphocytic leukemia developed a large cell lymphoma apparently derived from the same neoplastic B-cell clone (Richter's syndrome). At the same time, mitogen-stimulated proliferation of the patient's circulating leukemic B-cells was no longer inhibited by the regulatory cytokine transforming growth factor-beta (TGF-beta), suggesting that such loss of inhibition might be contributing to the clinical and biological progression of the disease.

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