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. 1994 Jan 6;367(6458):40-6.
doi: 10.1038/367040a0.

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

E Manser  1 , T Leung, H Salihuddin, Z S Zhao, L Lim
Affiliations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

E Manser et al. Nature. .

Abstract

A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.

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