[A pathogenetic study of the hemostatic system in patients with severe forms of eczema, atopic dermatitis and psoriasis (a review of the literature and the authors' own data)]

Abstract

Basing on literature and original data, the authors investigated mechanisms operating in coagulating and anticoagulant systems in patients with severe chronic dermatoses (eczema, atopic dermatitis, psoriasis) as well as interaction of the above systems. The general trend in prothrombin index, plasma recalcification time, fibrinogen in the period of active clinical symptoms in relevant dermatosis confirm the existence of hypercoagulant processes. A simultaneous rise in blood tolerance to heparin, in the total content of GAG and their sulfated and nonsulfated fractions may be resultant from increased anticoagulant blood properties. The analysis of coagulative indices and GAG levels in clinical remission showed minimal trends to normalization thereof, this being an indication of remaining tissue inflammation. High GAG levels are thought an essential pathogenetic issue responsible for persistence of hemostatic disorders and abnormalities in microcirculation due to elevated blood viscosity.