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Comparative Study
. 1993 Dec;37(12):2699-705.
doi: 10.1128/AAC.37.12.2699.

A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline

L M Hansen  1 , L M McMurry, S B Levy, D C Hirsh
Affiliations
Comparative Study

A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline

L M Hansen et al. Antimicrob Agents Chemother. 1993 Dec.

Abstract

The tetracycline resistance determinant on plasmid pVM111 from an avian strain of Pasteurella multocida mediates tetracycline resistance by a regulated active efflux mechanism. DNA coding for the determinant did not hybridize at high stringency with DNA representing a group of common tetracycline resistance determinants. The DNA sequence, however; revealed a structural gene and a repressor gene which had significant (37 to 64%) sequence similarities with previously described classes of efflux-type tetracycline resistance genes from members of the family Enterobacteriaceae. The new determinant has been assigned to class H.

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References

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