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Comparative Study
. 1993 Dec;37(12):2756-9.
doi: 10.1128/AAC.37.12.2756.

In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity

S Nakagawa  1 , T Hashizume, K Matsuda, M Sanada, O Okamoto, H Fukatsu, N Tanaka
Affiliations
Comparative Study

In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity

S Nakagawa et al. Antimicrob Agents Chemother. 1993 Dec.

Abstract

BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its broad spectrum merit further investigation for clinical use by itself, since it was stable in the presence of renal dehydropeptidase I.

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