Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Aug;34(4):326-31.
doi: 10.1136/ard.34.4.326.

Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli

A K Clarke, B Vernon-Roberts, H L Currey

Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli

A K Clarke et al. Ann Rheum Dis. 1975 Aug.

Abstract

The fluid and cellular phases of inflammatory resonse have been measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Phenylbutazone, azathioprine, aspirin, cyclophosphamide, and prednisolone suppressed fluid response, whereas sodium aurothiomalate, hydroxychloroquine, and D-penicillamine had no effect. All the drugs used suppressed the infiltration of inflammatory cells into the cubes.

PubMed Disclaimer

References

    1. AMA Arch Pathol. 1955 May;59(5):553-8 - PubMed
    1. Proc Soc Exp Biol Med. 1953 Feb;82(2):328-33 - PubMed
    1. Experientia. 1950 Dec 15;6(12):469-71 - PubMed
    1. Acta Chir Scand. 1971;137(7):639-42 - PubMed
    1. Ann Rheum Dis. 1973 Jul;32(4):301-7 - PubMed