Comparative Study
doi: 10.1016/0378-1119(94)90519-3.
Two novel deduced serine/threonine protein kinases from Saccharomyces cerevisiae
Affiliations
- PMID: 8112585
- DOI: 10.1016/0378-1119(94)90519-3
Item in Clipboard
Comparative Study
Two novel deduced serine/threonine protein kinases from Saccharomyces cerevisiae
Gene.
.
Abstract
We have cloned genes for two closely related protein kinase (PK) homologues from Saccharomyces cerevisiae. Sequence alignment of the kinase domain with previously characterized PK reveals the highest degree of similarity with second messenger-regulated kinases. RCK1 encodes a 58-kDa protein, and is weakly expressed. RCK2 encodes a 65-kDa protein, and transcripts from this gene are readily detected. RCK1 has been mapped to the L arm of chromosome VII, and RCK2 to chromosome XII. Disruption of these genes in the S. cerevisiae genome demonstrates that both genes are non-essential.
Similar articles
-
Cloning of chromosome I DNA from Saccharomyces cerevisiae: analysis of the FUN52 gene, whose product has homology to protein kinases.Gene. 1992 Aug 1;117(1):137-40. doi: 10.1016/0378-1119(92)90502-g. Gene. 1992. PMID: 1644305
-
NPK1, a nonessential protein kinase gene in Saccharomyces cerevisiae with similarity to Aspergillus nidulans nimA.Mol Gen Genet. 1992 Jul;234(1):164-7. doi: 10.1007/BF00272358. Mol Gen Genet. 1992. PMID: 1495480
-
A putative serine/threonine protein kinase gene on chromosome III of Saccharomyces cerevisiae.Yeast. 1992 Jan;8(1):71-7. doi: 10.1002/yea.320080108. Yeast. 1992. PMID: 1580103
-
Human genetic diseases: a cross-talk between man and yeast.Gene. 1997 Aug 11;195(1):1-10. doi: 10.1016/s0378-1119(97)00140-6. Gene. 1997. PMID: 9300813 Review.
-
Sequencing the yeast genome: an international achievement.Yeast. 1994 Dec;10(13):1689-706. doi: 10.1002/yea.320101304. Yeast. 1994. PMID: 7747513 Review.
Cited by
-
Degradation of Saccharomyces cervisiae Rck2 upon exposure of cells to high levels of zinc is dependent on Pep4.Mol Genet Genomics. 2005 Jun;273(5):433-9. doi: 10.1007/s00438-005-1151-8. Epub 2005 May 11. Mol Genet Genomics. 2005. PMID: 15887030
-
Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1.Mol Genet Genomics. 2003 Feb;268(5):585-97. doi: 10.1007/s00438-002-0786-y. Epub 2003 Jan 15. Mol Genet Genomics. 2003. PMID: 12589433
-
Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1.Mol Cell Biol. 2000 Jun;20(11):3887-95. doi: 10.1128/MCB.20.11.3887-3895.2000. Mol Cell Biol. 2000. PMID: 10805732 Free PMC article.
-
The yeast histidine protein kinase, Sln1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p.EMBO J. 1998 Dec 1;17(23):6952-62. doi: 10.1093/emboj/17.23.6952. EMBO J. 1998. PMID: 9843501 Free PMC article.
-
Cytoplasmatic post-transcriptional regulation and intracellular signalling.Mol Genet Genomics. 2007 Apr;277(4):341-55. doi: 10.1007/s00438-007-0221-5. Epub 2007 Mar 1. Mol Genet Genomics. 2007. PMID: 17333280 Review.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
