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. 1993;38(4):349-52.
doi: 10.1007/BF02898607.

Alterations in Pseudomonas aeruginosa exoproducts by sub-MICs of some antibiotics

A Hostacká  1 , V Majtán
Affiliations

Alterations in Pseudomonas aeruginosa exoproducts by sub-MICs of some antibiotics

A Hostacká et al. Folia Microbiol (Praha). 1993.

Abstract

Aminoglycoside antibiotics, most effective at the level of 1/4 of the MIC, suppressed all the tested activities of P. aeruginosa, except cytotoxicity. Proteinase activity was decreased to 60% (gentamicin) and 63% (streptomycin), permeability was reduced to 61% (gentamicin) and 73% (streptomycin), phospholipase C to 13% (gentamicin) and 51% (streptomycin) of the control values. Subinhibitory concentrations of beta-lactams inhibited only phospholipase C activity to 89% (ticarcillin) and 64% (cefotaxim) of the control values. These antibiotics did not suppress the cytotoxic activity and increased protease activity up to 155% (ticarcillin) and 192% (cefotaxim) as well as permeability up to 121% (ticarcillin) and 154% (cefotaxim) of the control values.

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