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. 1994 Mar 1;179(3):1047-52.
doi: 10.1084/jem.179.3.1047.

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages

E Lagasse  1 , I L Weissman
Affiliations

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages

E Lagasse et al. J Exp Med. .

Abstract

Neutrophils, the most common inflammatory leukocytes, have the most limited life span of all blood cells. After they undergo apoptosis, they are recognized and engulfed by macrophages. bcl-2, a proto-oncogene rearranged and deregulated in B cell lymphomas bearing the t(14;18) translocation, is known to inhibit programmed death. bcl-2 expression is localized in early myeloid cells of the bone marrow but is absent in mature neutrophils. Transgenic mice that expressed bcl-2 in mature neutrophils showed that bcl-2 blocked neutrophil apoptosis. Despite this, homeostasis of neutrophil population is essentially unaffected. In fact, macrophage uptake of neutrophils expressing bcl-2 still occurred. This transgenic model indicates that the mechanism that triggers phagocytosis of aging neutrophils operates independently of the process of apoptosis regulated by bcl-2.

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