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. 1993 Oct;29A(10):782-8.
doi: 10.1007/BF02634345.

A 29,000 molecular weight fraction from fetal rat liver adhering cells that cooperates with erythropoietin in stimulating the growth of erythroid progenitors

M D Nagel  1
Affiliations

A 29,000 molecular weight fraction from fetal rat liver adhering cells that cooperates with erythropoietin in stimulating the growth of erythroid progenitors

M D Nagel. In Vitro Cell Dev Biol Anim. 1993 Oct.

Abstract

The erythroid-potentiating effects of a protein fraction produced by 20-day rat fetal liver-adhering cells are studied. Partial purification by gel filtration gave an active fraction (apparent molecular weight = 29 x 10(3)) that significantly increased the erythroid colony counts (CFUe and late BFUe) in cultures of liver cell fractions depleted of adhering cells at both limiting and saturating concentration of recombinant human erythropoietin. The sensitivity of CFUe and BFUe to erythropoietin was increased by the activator.

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