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Review
. 1993 Dec;9(12):413-21.
doi: 10.1016/0168-9525(93)90104-p.

Site-specific recombinases: tools for genome engineering

N J Kilby  1 , M R Snaith, J A Murray
Affiliations
Review

Site-specific recombinases: tools for genome engineering

N J Kilby et al. Trends Genet. 1993 Dec.

Abstract

Site-specific recombinases from bacteriophage and yeasts have been developed as novel tools for manipulating DNA both in the test-tube and in living organisms. We discuss the characteristics of these enzyme systems, review their application in genetic and developmental studies and speculate on their future potential for large-scale directed modifications of eukaryotic genomes.

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