doi: 10.1016/0005-2760(94)90146-5.
Hepatic lipase mRNA is expressed in rat and human steroidogenic organs
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- PMID: 8123676
- DOI: 10.1016/0005-2760(94)90146-5
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Hepatic lipase mRNA is expressed in rat and human steroidogenic organs
Biochim Biophys Acta.
.
Free article
Abstract
Rat and human steroidogenic organs contain an enzyme activity that is indistinguishable from hepatic lipase present in liver. Using primers that recognize exons 5 and 8 of the rat and human HL gene, a 596-bp product was found by RT-PCR in rat liver, adrenal, ovaries and testes, but not in heart and kidney. A similar product was also observed with human hyperplastic adrenocortical tissue. Identity of this product with part of the HL cDNA was confirmed by restriction mapping and internal re-amplification. Our results indicate that the HL gene is transcribed in steroidogenic tissues that also contain HL protein.
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