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. 1993 Dec;44(4):383-90.

The influence of PGE1 and ethanol as PGE1 solvent on the activity of galactosyltransferase of rat liver Golgi fractions--in vitro experiments

A M Kordowiak  1 , J Stachura, J Tomecki, P Kapusta
Affiliations
  • PMID: 8123885

The influence of PGE1 and ethanol as PGE1 solvent on the activity of galactosyltransferase of rat liver Golgi fractions--in vitro experiments

A M Kordowiak et al. J Physiol Pharmacol. 1993 Dec.

Abstract

Addition in vitro of ethanol solution of PGE1 to isolated Golgi-rich membrane fraction caused great alterations in galactosyltransferase activity, marker enzyme of these membranes. Ethanol as a solvent of PGE1 has an influence on the activity of the enzyme as well as the membrane permeability, different drugs penetration and availability of substrates. Then, additional control with ethanol in identical concentration as in the investigated sample was performed. In a dose 1 microgram PGE1 per 1 mg of protein (and lower concentration of ethanol c. 0.09%) the stimulation of this enzyme activity (excluding 2 and 6 hours s after Golgi membrane isolation) was above 30% in comparison with the control.

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