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. 1994 Jan;42(1):19-26.
doi: 10.1248/cpb.42.19.

Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers

M Kobayashi  1 , K Kawazoe, T Okamoto, T Sasaki, I Kitagawa
Affiliations
Free article

Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers

M Kobayashi et al. Chem Pharm Bull (Tokyo). 1994 Jan.
Free article

Abstract

Acidic treatment of swinholide A (1), which was characterized as the major cytotoxic macrolide from the Okinawan marine sponge Theonella swinhoei, provided several isomeric macrolides having different size of the dilactone ring structure. From the structure-activity correlation viewpoint, the in vitro cytotoxicities and in vivo antitumor activities of these dimeric macrolides, together with two monomeric macrolides which were synthesized from 1, have been examined.

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