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. 1976 Jan 10;1(6001):70-2.
doi: 10.1136/bmj.1.6001.70.

Phenformin and lactic acidosis

P H Wise, M Chapman, D W Thomas, A R Clarkson, P E Harding, J B Edwards

Phenformin and lactic acidosis

P H Wise et al. Br Med J. .

Abstract

Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for lactic acidosis. Advanced age and cardiovascular and renal disease are absolute contraindications to the use of phenformin in diabetics.

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