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. 1994 Feb 11;22(3):485-91.
doi: 10.1093/nar/22.3.485.

Intramolecular recombination in polyomavirus DNA is controlled by promoter elements

C Nault  1 , S Veilleux, L Delbecchi, D Bourgaux-Ramoisy, P Bourgaux
Affiliations
Free PMC article

Intramolecular recombination in polyomavirus DNA is controlled by promoter elements

C Nault et al. Nucleic Acids Res. .
Free PMC article

Abstract

We show here that intramolecular homologous recombination in polyomavirus (Py) DNA depends upon discrete sequence elements of the viral regulatory region which are believed to regulate transcription initiation and exert little or no cis-control over replication. Either deleting the viral early promoter (EP) or inverting the viral late promoter (LP) strongly impairs viral DNA recombination under conditions allowing viral DNA replication to proceed undisturbed. These findings suggest that bi-directional transcription proceeding from the intergenic region favors intramolecular recombination.

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