Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Mar 11;263(5152):1453-4.
doi: 10.1126/science.8128231.

Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes

M Kondo  1 , T Takeshita, M Higuchi, M Nakamura, T Sudo, S Nishikawa, K Sugamura
Affiliations

Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes

M Kondo et al. Science. .

Abstract

The gamma chain of the interleukin-2 (IL-2) receptor is shared with the functional IL-4 receptor and is causatively related to X-linked severe combined immunodeficiency (XSCID), which is ascribed to a profound T cell defect. Studies with monoclonal antibodies specific for the IL-2 receptor gamma chain showed that the gamma chain participates in the functional high-affinity receptor complexes for IL-7 that are involved in the differentiation of T and B cells. Participation of the gamma subunit in more than one receptor may enable the elucidation of the mechanisms of XSCID development and lymphocyte differentiation.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources