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Comparative Study
. 1994 Feb;53(2):100-5.
doi: 10.1136/ard.53.2.100.

Chlamydia pneumoniae--a new causative agent of reactive arthritis and undifferentiated oligoarthritis

J Braun  1 , S Laitko, J Treharne, U Eggens, P Wu, A Distler, J Sieper
Affiliations
Comparative Study

Chlamydia pneumoniae--a new causative agent of reactive arthritis and undifferentiated oligoarthritis

J Braun et al. Ann Rheum Dis. 1994 Feb.

Abstract

Objective: To examine whether reactive arthritis (ReA) known to occur after a urogenital infection with Chlamydia trachomatis can also follow an infection with Chlamydia pneumoniae, a recently described species of Chlamydiae that is a common cause of respiratory tract infections.

Methods: Specific antibodies (microimmunofluorescence test) and lymphocyte proliferation to C trachomatis and C pneumoniae in paired samples of peripheral blood and synovial fluid were investigated in 70 patients with either reactive arthritis (ReA) or undifferentiated oligoarthritis (UOA).

Results: Five patients with acute ReA after an infection with C pneumoniae are reported. Three had a symptomatic preceding upper respiratory tract infection and two had no such symptoms. In all patients a C pneumoniae-specific lymphocyte proliferation in synovial fluid and a high specific antibody titre suggesting an acute infection was found.

Conclusion: C pneumoniae needs to be considered a new important cause of reactive arthritis.

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