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Case Reports
. 1993 Dec;24(6):339-40.
doi: 10.1055/s-2008-1071568.

Lamotrigine in Rett syndrome

P Uldall  1 , F J Hansen, B Tonnby
Affiliations
Case Reports

Lamotrigine in Rett syndrome

P Uldall et al. Neuropediatrics. 1993 Dec.

Abstract

An elevated CSF glutamate level has recently been reported in Rett syndrome. Because the anticonvulsant effect of Lamotrigine is probably due to inhibition of glutamate release, this drug was given as an add-on drug to 4 girls with Rett syndrome. All patients responded with a seizure reduction of 50% or more and an improved well-being. A controlled study at the early stages of the syndrome could be interesting.

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