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. 1993 Nov-Dec;14(6):1091-3.
doi: 10.1016/0196-9781(93)90160-i.

Antitumoral cyclic peptide analogues of chlamydocin

E Bernardi  1 , J L Fauchere, G Atassi, P Viallefont, R Lazaro
Affiliations

Antitumoral cyclic peptide analogues of chlamydocin

E Bernardi et al. Peptides. 1993 Nov-Dec.

Abstract

A series of cyclic tetrapeptides bearing the bioactive alkylating group on an epsilon-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One analogue belonging to the chlamydocin family and bearing a beta-chloroethylnitrosourea group was found to be potent at inhibiting L1210 cell proliferation and had a higher therapeutic index than the reference compound bis-beta-chloroethylnitrosourea (BCNU) on the in vivo P388-induced leukemia model.

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