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Comparative Study
. 1994 Apr;191(1):41-51.
doi: 10.1148/radiology.191.1.8134596.

Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings

H J Aronen  1 , I E Gazit, D N Louis, B R Buchbinder, F S Pardo, R M Weisskoff, G R Harsh, G R Cosgrove, E F Halpern, F H Hochberg, et al.
Affiliations
Comparative Study

Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings

H J Aronen et al. Radiology. 1994 Apr.

Abstract

Purpose: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas.

Materials and methods: CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material.

Results: The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity.

Conclusion: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.

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