Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease
- PMID: 81354
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Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease
Lab Invest.
1978 Oct.
Abstract
Human polymorphonuclear lysosomal granules contain a neutral protease which is capable of digesting human immunoglobulins. The protease is located in the azurophil granules and enzymatically cleaves IgG, producing a Fab-like piece which is recoverable. The Fc-like fragment is not crystallized. The Fab-like fragment competes effectively for ligands formed by native antibody from which the fragments were produced.
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