Anaplerotic effect of propionyl carnitine in rat heart mitochondria

Abstract

Carnitine and propionyl carnitine both increase production of 14CO2 from [1-14C]pyruvate but only the latter, in a process inhibited by malonate, increases oxygen uptake and 14CO2 evolution from [2-14C]pyruvate. Carnitine increases the rate of formation of acetyl carnitine from pyruvate to a greater extent than propionyl carnitine. These effects of carnitine and propionyl carnitine are not detectable in mitochondria (e.g., rat liver) deficient in carnitine acetyl transferase activity.