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Review
. 1994 Jan;15(1):7-10.
doi: 10.1016/0167-5699(94)90018-3.

Oxidative stress as a mediator of apoptosis

T M Buttke  1 , P A Sandstrom
Affiliations
Review

Oxidative stress as a mediator of apoptosis

T M Buttke et al. Immunol Today. 1994 Jan.

Abstract

Many agents which induce apoptosis are either oxidants or stimulators of cellular oxidative metabolism. Conversely, many inhibitors of apoptosis have antioxidant activities or enhance cellular antioxidant defenses. Mammalian cells exist in a state of oxidative siege in which survival requires an appropriate balance of oxidants and antioxidants. Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.

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Comment in

  • Apoptosis, anti-apoptotic compounds and TNF-alpha release.
    Famularo G, De Simone C, Tzantzoglou S, Trinchieri V. Famularo G, et al. Immunol Today. 1994 Oct;15(10):495-6. doi: 10.1016/0167-5699(94)90196-1. Immunol Today. 1994. PMID: 7945776 No abstract available.
  • Oxidative stress and apoptosis.
    Fuchs D, Gruber A, Uberall F, Wachter H. Fuchs D, et al. Immunol Today. 1994 Oct;15(10):496. doi: 10.1016/0167-5699(94)90197-X. Immunol Today. 1994. PMID: 7945777 No abstract available.

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