Parvovirus B19-related lymphadenopathy

Abstract

We tested whether parvovirus B19 (PVB19) is involved in benign lymph node swelling as a causative agent. The serum specimens from 13 patients with lymph node swelling of unidentified cause were tested for IgM and IgG antibody against PVB19 by Western blot analysis. Five patients had IgM antibody, and PVB19 DNA was detected in the serum from one of them by dot-blot analysis, suggesting the recent PVB19 infection and its involvement in lymph node swelling of these patients. Clinical and haematological features of the patients are also discussed.