Malarial infections in Aotus trivirgatus with special reference to renal pathology. II. P. falciparum and mixed malaria infections

Abstract

This paper describe the renal pathology in Aotus trivirgatus (owl monkeys) following P. falciparum infections and also when the initial P. falciparum was followed by infection with P. malariae or P. brrasilianum. Acute P. falciparum infections were associted with high parasitaemia but relatively mild changes in the glomeruli. This was also the case when a second infection with P. falciparum was given after the first infection had been terminated with chloroquine. Four monkeys with multiple infections involving P. Malariae or P. brasilianum after P. falciparum showed a glomerulonephritis. Two of these also showed a necrotizing arteriolitis. The findings suggest that P. falciparum alone does not give progressive renal disease and that this is more likely to occur with mixed infections.