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. 1994 Jan 4;251(1):R1-2.
doi: 10.1016/0014-2999(94)90453-7.

NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain

S Chaki  1 , M Tanaka, M Muramatsu, S Otomo
Affiliations

NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain

S Chaki et al. Eur J Pharmacol. .

Abstract

The selectivity of N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE-100) for sigma 1 and sigma 2 binding sites was studied by means of binding of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine ([3H]DTG) in guinea pig brain. NE-100 inhibited [3H](+)-pentazocine binding to sigma 1 binding sites potently with an IC50 value of 1.54 +/- 0.26 nM while it had a weak effect on [3H]DTG binding to sigma 2 binding sites. The inhibitory effect of NE-100 on [3H](+)-pentazocine was 55 times more potent than that on [3H]DTG binding. These results suggest that NE-100 is a potent and selective ligand for sigma 1 binding sites.

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