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. 1994 Mar 21;341(2-3):182-6.
doi: 10.1016/0014-5793(94)80453-2.

cDNA cloning, expression and primary structure of Par jI, a major allergen of Parietaria judaica pollen

M A Costa  1 , P Colombo, V Izzo, H Kennedy, S Venturella, R Cocchiara, G Mistrello, P Falagiani, D Geraci
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Free article

cDNA cloning, expression and primary structure of Par jI, a major allergen of Parietaria judaica pollen

M A Costa et al. FEBS Lett. .
Free article

Abstract

A 659 bp cDNA clone** coding for an allergen of Pj pollen has been isolated from a lambda gt11 library, and its DNA sequence determined. The cDNA insert showed an open reading frame of 429 bp coding for an allergenic protein of 14,866 Da and a deduced amino acid sequence containing 143 residues. The expressed recombinant protein represented the major allergen Par jI since it reacted with 95% of the sera from Pj-allergic patients (n = 22) and with two Par jI-specific monoclonal antibodies. No similarity with other known DNA and protein sequences has been detected.

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