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. 1994 Jan;19(1):1-4.
doi: 10.1007/BF00966719.

Effect of penicillin on GABA-gated chloride ion influx

A Tsuda  1 , M Ito, K Kishi, H Shiraishi, H Tsuda, C Mori
Affiliations

Effect of penicillin on GABA-gated chloride ion influx

A Tsuda et al. Neurochem Res. 1994 Jan.

Abstract

To investigate the mechanism of penicillin-induced convulsions, we have studied the effects of penicillin G (PC-G) on GABA-gated chloride ion influx in brain 'microsac' preparations of mice. In the presence of 10(-4) M GABA, PC-G inhibited GABA-gated chloride ion influx in a dose-dependent manner. The dose-response curve for GABA in the presence of 10(-3) M PC-G was shifted rightward and there was a decrease in maximum response. The inhibitory effects of PC-G were not reversed by RO 15-1788, an antagonist of benzodiazepine (BZ) receptors, but were reversed by washing the 'microsac' membranes. Therefore, PC-G probably exerts its proconvulsant effect by inhibiting GABA-gated chloride ion influx. However, it appears not to act through the BZ receptor of the GABA/BZ receptor complex.

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