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. 1978 Oct 21;2(8095):871-2.
doi: 10.1016/s0140-6736(78)91573-8.

Haemolytic-uraemic syndrome: deficiency of plasma factor(s) regulating prostacyclin activity?

G Remuzzi, R Misiani, D Marchesi, M Livio, G Mecca, G de Gaetano, M B Donati

Haemolytic-uraemic syndrome: deficiency of plasma factor(s) regulating prostacyclin activity?

G Remuzzi et al. Lancet. .

Abstract

It is suggested that patients with the haemolytic-uraemic syndrome and related disorders (such as thrombotic thrombocytopenic purpura) lack a plasma factor which stimulates prostacyclin (P.G.I2) activity. Normal plasma would supply the missing factor and is a rational treatment for some life-threatening symptoms (thrombocytopenia, haemolytic anaemia, hypertension) of this syndrome.

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