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Review
. 1993 Jun;1(3):81-7.
doi: 10.1016/0966-842x(93)90112-5.

Protease-dependent virus tropism and pathogenicity

Y Nagai  1
Affiliations
Review

Protease-dependent virus tropism and pathogenicity

Y Nagai. Trends Microbiol. 1993 Jun.

Erratum in

  • Trends Microbiol 1993 Jul;1(4):135

Abstract

Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the receptor. These events are now explained by another mechanism of tropism, in which host proteases play a major role by activating viral fusion glycoproteins.

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