Review
doi: 10.1016/0966-842x(93)90112-5.
Protease-dependent virus tropism and pathogenicity
Affiliations
- PMID: 8143121
- PMCID: PMC7133224
- DOI: 10.1016/0966-842x(93)90112-5
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Review
Protease-dependent virus tropism and pathogenicity
Trends Microbiol.
1993 Jun.
Erratum in
- Trends Microbiol 1993 Jul;1(4):135
Abstract
Viral tissue tropism in a susceptible host is often determined by virus-receptor interactions. Nevertheless, closely related viruses utilizing the same receptor molecules can display striking differences in tropism, or a virus can cause a localized infection despite the widespread occurrence of the receptor. These events are now explained by another mechanism of tropism, in which host proteases play a major role by activating viral fusion glycoproteins.
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