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. 1993 Jul;1(4):153-6.
doi: 10.1016/0966-842x(93)90131-a.

Human endogenous retroviral elements and autoimmunity: data and concepts

A Perl  1 , K Banki
Affiliations

Human endogenous retroviral elements and autoimmunity: data and concepts

A Perl et al. Trends Microbiol. 1993 Jul.

Abstract

The human genome contains a complex variety of inherited endogenous retroviral sequences (ERSs), several of which are transcriptionally active and contain open reading frames. Aberrant expression of ERSs and generation of antibodies to ERS-encoded proteins have recently been revealed in autoimmune disorders. Involvement of ERSs could explain both the familial aggregation and the detection of antiretroviral antibodies in autoimmune diseases.

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