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Review
. 1994 Mar 15;50(3):192-203.
doi: 10.1007/BF01924002.

Structure and function of RecA-DNA complexes

A Stasiak  1 , E H Egelman
Affiliations
Review

Structure and function of RecA-DNA complexes

A Stasiak et al. Experientia. .

Abstract

While the E. coli RecA protein has been the most intensively studied enzyme of homologous recombination, the unusual RecA-DNA filament has stood alone until very recently. It now appears that this protein is part of a universal family that spans all of biology, and the filament that is formed by the protein on DNA is a universal structure. With RecA's role in recombination given new and greatly increased significance, we focus in this review on the energetics of the RecA-mediated strand exchange and the relation between the energetics and recombination spanning heterologous inserts.

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